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Water → HCID 22396256, 화합물

HRID 1070495
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HRID 1070495 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:11]=[C:10]([CH2:12][CH2:13][C:14]([NH:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:15])[O:9][N:8]=1.FC(F)(F)C(O)=O.O.[OH-].[Na+]>ClCCl>[NH:20]1[CH2:21][CH2:22][CH:17]([NH:16][C:14](=[O:15])[CH2:13][CH2:12][C:10]2[O:9][N:8]=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[N:11]=2)[CH2:18][CH2:19]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 22396212HCID 22396212, 화합물

생성물 1

HCID 22396256HCID 22396256, 화합물수율 63.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

tert-Butyl 4-({3-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]propanoyl}amino)-1-piperidinecarboxylate (0.40 g) was dissolved in dichloromethane (6 ml) and trifluoroacetic acid (3 ml) was added. After 2 hours water, 2N sodium hydroxide and dichloromethane were added and the phases were separated. The organic phase was dried, filtered and evaporated to give the subtitle compound (0.19 g).

후처리

  1. customthe phases were separated
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-68de14e37e9b455b94742b718f2f2d72
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06903085B1

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