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Water → 2-Chloro-N-[1-[(3,4-difluorophenyl)methyl]-piperidin-4-yl]-acetamide

HRID 1070496
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HRID 1070496 반응식
Cl.Cl.[F:3][C:4]1[CH:5]=[C:6]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[F:10].C(N(C(C)C)CC)(C)C.[Cl:28][CH2:29][C:30](Cl)=[O:31].O>O1CCCC1.[Cl-].[Na+].O.C(OCC)(=O)C>[Cl:28][CH2:29][C:30]([NH:18][CH:15]1[CH2:16][CH2:17][N:12]([CH2:11][C:6]2[CH:7]=[CH:8][C:9]([F:10])=[C:4]([F:3])[CH:5]=2)[CH2:13][CH2:14]1)=[O:31]
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참가 물질

8

반응물 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 532561271-(3,4-Difluorobenzyl)piperidin-4-amine dihydrochloride

생성물 1

HCID 223961822-Chloro-N-[1-[(3,4-difluorophenyl)methyl]-piperidin-4-yl]-acetamide수율 22.6%

시약·촉매·용매 3

HCID 8028
Tetrahydrofuran
용매
HCID 8857Ethyl Acetate용매
HCID 57417360Sodium chloride; water용매

실험 절차

1-[(3,4-Difluorophenyl)methyl]-piperidin-4-ylamine dihydrochloride (3.18 g) was dissolved in tetrahydrofuran (40 ml). Diisopropylethlamine (6.84 g) and chloroacetyl chloride (1.33 g) were added. After 3 hours water, brine and ethyl acetate were added the phase were separated. The organic phase was dried, filtered and evaporated and the residue was purified by chromatography eluting with ethyl acetate to give the subtitle compound (0.728 g).

후처리

  1. customwere separated
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customevaporated
  5. customthe residue was purified by chromatography
  6. washeluting with ethyl acetate

출처 및 근거

ORD 기록
ord-cc62249076d64857a51d9fc8ac260f00
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06903085B1

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