Succinic anhydride → HCID 22396185, 화합물

HRID 1070501노트

반응식

HRID 1070501 반응식
[OH:1]/[N:2]=[C:3](\[NH2:13])/[CH2:4][S:5]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)(=[O:7])=[O:6].[O:14]1[C:18](=O)[CH2:17][CH2:16][C:15]1=[O:20]>CN(C)C=O>[S:9]1[CH:10]=[CH:11][CH:12]=[C:8]1[S:5]([CH2:4][C:3]1[N:13]=[C:18]([CH2:17][CH2:16][C:15]([OH:20])=[O:14])[O:1][N:2]=1)(=[O:6])=[O:7]

참가 물질

4

반응물 2

HCID 7922Succinic anhydrideHCID 9582211N'-Hydroxy-2-(2-thienylsulfonyl)ethanimidamide

생성물 1

HCID 22396185HCID 22396185, 화합물수율 96.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(1Z)-N′-hydroxy-2-(2-thienylsulfonyl)ethanimidamide (0.250 g) with dihydro-2,5-furandione (0.114 g) in dimethylformamide (0.2 ml) was heated at 120° C. for 2 hours. The reaction was allowed to cool and triturated with diethyl ether and filtered to leave 3-{3-[(2-thienylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl}propanoic acid (0.332 g).

후처리

  1. temperatureto cool
  2. customtriturated with diethyl ether
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-b049fb50241c422a90aefd5d73421358
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903085B1

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