Formamide → 4-[4-(4-Chlorophenylamino)phthalazin-1-yloxymethyl]pyridin-2-yl carboxylic acid amide

HRID 1070530노트

반응식

HRID 1070530 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[N:11][N:10]=2)=[CH:4][CH:3]=1.[CH:27]([NH2:29])=[O:28]>ClCCl.CC(C)=O.C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([O:19][CH2:20][C:21]3[CH:22]=[CH:23][N:24]=[C:25]([C:27]([NH2:29])=[O:28])[CH:26]=3)=[N:11][N:10]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 713FormamideHCID 22397275N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine

생성물 1

HCID 99092664-[4-(4-Chlorophenylamino)phthalazin-1-yloxymethyl]pyridin-2-yl carboxylic acid amide수율 10%

시약·촉매·용매 1

HCID 86759755Dichloromethane acetone triethylamine용매

실험 절차

The general procedure used for the preparation of Example 4 was used to prepare 5 from 1-(4-chlorophenylamino)-4-(4-pyridylmethoxy)phthalazine and formamide; (10% yield). TLC (dichloromethane/acetone/triethylamine 7.5:1.0:0.5): Rf=0.42.

후처리

  1. customThe general procedure used for the preparation of Example 4

출처 및 근거

ORD 기록
ord-a5a5bfa4bd224327a6b5303c96444939
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903101B1

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