Methyl iodide → 1,2,2,6,6-Pentamethyl-4-piperidone hydroiodide

HRID 1070698

반응식

HRID 1070698 반응식
O.[CH3:2][C:3]1([CH3:12])[CH2:8][C:7](=[O:9])[CH2:6][C:5]([CH3:11])([CH3:10])[NH:4]1.[CH3:13][I:14]>C(O)(C)C>[IH:14].[CH3:13][N:4]1[C:5]([CH3:11])([CH3:10])[CH2:6][C:7](=[O:9])[CH2:8][C:3]1([CH3:12])[CH3:2]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 223976024-Piperidinone, 2,2,6,6-tetramethyl-, monohydrate

생성물 1

HCID 223975731,2,2,6,6-Pentamethyl-4-piperidone hydroiodide수율 46%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A solution of 2,2,6,6-tetramethyl-4-piperidone monohydrate (40 g, 23.1 mmol) and methyl iodide (98.31 g, 69.3 mmol) in isopropyl alcohol (25 mL) was stirred at RT for 48 hours. The resulting suspension was filtered, the solid residue was dried and recrystallized from MeOH. After filtration and repeated washings with MeOH the solid was dried giving pure title compound (31.6 g, 10.6 mmol, yield 46.0%) as pale brown crystals.

후처리

  1. filtrationThe resulting suspension was filtered
  2. customthe solid residue was dried
  3. customrecrystallized from MeOH
  4. filtrationAfter filtration
  5. washwashings with MeOH the solid
  6. customwas dried

출처 및 근거

ORD 기록
ord-c9f3ab24e3d249ab9e8e55d965ecc83a
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903117B2

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