Methanol → HCID 10237195, 화합물

HRID 1070896노트

반응식

HRID 1070896 반응식
[N+](=[CH2:3])=[N-].C(OCC)C.[C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([OH:31])=[O:30])=[O:23])(O)=[O:10].[CH3:33][OH:34]>O1CCCC1>[CH3:33][O:34][C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([O:31][CH3:3])=[O:30])=[O:23])=[O:10]

참가 물질

6

반응물 4

HCID 887MethanolHCID 3283Diethyl EtherHCID 9550DiazomethaneHCID 125516Miridesap

생성물 1

HCID 10237195HCID 10237195, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of diazomethane in diethylether (˜6 mmol) was added to a solution of 500 mg (1.5 mmol) (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid in 10 ml tetrahydrofuran. After stirring overnight methanol was added and the solvents were evaporated. The residue was taken up in dichloromethane, extracted with brine and dried with sodium sulfate. After separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester were obtained as a light yellow oil, MS m/e (%): 369 (M+H+, 100).

후처리

  1. additionwas added
  2. customthe solvents were evaporated
  3. extractionextracted with brine
  4. dry with materialdried with sodium sulfate
  5. customAfter separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester
  6. customwere obtained as a light yellow oil, MS m/e (%)

출처 및 근거

ORD 기록
ord-41614dc46b954e06ae130b5b54701c64
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903129B2

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