다이아조메테인(디아조메탄)

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. Combat fire from a sheltered position.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention. Wear protective gloves when administering first aid.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Keep rinsing during transport for medical attention.

Unlikely under occupational conditions.

Excerpt from NIOSH Pocket Guide for Diazomethane:

(General first aid procedures)

If material /is/ on fire or involved in /a/ fire use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Fires involving diazomethane should be fought upwind from the maximum distance possible. Diazomethane will explode in a fire. The fire area should be evacuated immediately. Keep unnecessary people away; isolate the hazard area and deny entry. Vapors may travel to a source of ignition and flash back. Vapors are an explosion and poison hazard indoors, outdoors, or in sewers.

Diazomethane should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard. Containers of diazomethane should be protected from shock, heat, sparks, open flames and physical damage and should be stored separately from alkali metals, calcium sulfate, calcium chloride, boiling stones, or copper powder. Outside or detached storage is preferred. Empty containers of diazomethane should be handled appropriately.

Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane. ...

... Diazomethane must be stored to avoid contact with alkali metals , such as lithium, sodium, or potassium; or drying agents such as calcium sulfate, since violent reactions occur. Safety barriers or shields should be used to protect workers from accidental explosions. ...

In the event of a spill or leak involving diazomethane, persons not wearing protective equipment and clothing should be restricted from contaminated areas until cleanup has been completed. The following steps should be undertaken following a spill or leak: Notify safety personnel. Remove all sources of heat and ignition. Ventilate potentially explosive atmospheres. Provide and require the use of fully-encapsulating, vapor-protective clothing and equipment for cleanup personnel. If possible without risk, stop flow of gas. If source of leak is a cylinder and cannot be stopped in place, remove the leaking cylinder to a safe place in the open air, and repair leak or allow cylinder to empty. If the leak is in the liquid form, allow diazomethane to evaporate.

Decompose chemically with ceric ammonium nitrate under constant agitation and cooling.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

DIAZOMETHANE MAY BE DISPOSED OF BY BURNING AT SAFE LOCATION OR IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

EXPLOSIVE (USE SAFETY SCREEN), INSIDIOUS POISON (WELL-VENTILATED HOOD IS ABSOLUTELY NECESSARY), AVOID VAPOR.

If material /is/ not on fire and not involved in /a/ fire, keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. Do not use water on material itself. Neutralize spilled material with crushed limestone, soda ash, or lime.

Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.

If diazomethane contacts the skin, workers should flush the affected areas immediately with plenty of water, followed by washing with soap and water. Clothing contaminated with diazomethane should be removed immediately, and provisions should be made for the safe removal of the chemical from the clothing. Persons laundering the clothes should be informed of the hazardous properties of diazomethane, particularly its potential for causing severe irritation.

For more Preventive Measures (Complete) data for DIAZOMETHANE (9 total), please visit the HSDB record page.

TERRESTRIAL FATE: Since diazomethane is a gas and undergoes rapid hydrolysis with water, volatilization from soil is not relevant. Similarly, adsorption to soil and biodegradation are not expected due to the rapid rate of decomposition under environmental conditions. (SRC)

AQUATIC FATE: Since diazomethane is a gas and undergoes rapid hydrolysis with water, volatilization from water is not relevant. Similarly, hydrolysis, adsorption to sediments, bioconcentration, and biodegradation are not expected due to the rapid rate of decomposition under environmental conditions. (SRC)

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diazomethane, which has an estimated vapor pressure of 3.94X10+3 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a gas. Gas-phase diazomethane will undergo rapid hydrolysis with atmospheric water vapor but may also be degraded by reaction with photochemically-produced hydroxyl radicals at a much slower rate(SRC); the half-life for this reaction in air is estimated to be 16 days(SRC), calculated from its rate constant of 9.34X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The rate constant for the gas-phase reaction of diazomethane with ozone was 3.3X10-17 cu cm/molecule-sec(4). Diazomethane does not contain chromophores that absorb at wavelengths >290 nm(5), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

Sore throat. Headache. Laboured breathing. Shortness of breath. Nausea. Vomiting. Symptoms may be delayed.

Redness. Pain. Skin burns. Burning sensation. ON CONTACT WITH LIQUID: FROSTBITE.

Burning sensation. Redness. Pain. Burns. Loss of vision. ON CONTACT WITH LIQUID: FROSTBITE.

irritation eyes; cough, short breath; headache, lassitude (weakness, exhaustion); flush skin, fever; chest pain, pulmonary edema, pneumonitis; asthma; liquid: frostbite

Medical Screening: Workers who may be exposed to chemical hazards should be monitored in a systematic program of medical surveillance that is intended to prevent occupational injury and disease. The program should include education of employers and workers about work-related hazards, early detection of adverse health effects, and referral of workers for diagnosis and treatment. The occurrence of disease or other work-related adverse health effects should prompt immediate evaluation of primary preventive measures (e.g., industrial hygiene monitoring, engineering controls, and personal protective equipment). A medical surveillance program is intended to supplement, not replace, such measures. To detect and control work-related health effects, medical evaluations should be performed (1) before job placement, (2) periodically during the term of employment, and (3) at the time of job transfer or termination.

Pre-placement medical evaluation: Before a worker is placed in a job with a potential for exposure to diazomethane, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks. These should concentrate on the function and integrity of the eyes, skin, and respiratory tract. Medical surveillance for respiratory disease should be conducted using the principles and methods recommended by the American Thoracic Society. A pre-placement medical evaluation is recommended to assess medical conditions that may be aggravated or may result in increased risk when a worker is exposed to diazomethane at or below the prescribed exposure limit. The health care professional should consider the probable frequency, intensity, and duration of exposure as well as the nature and degree of any applicable medical condition. Such conditions (which should not be regarded as absolute contraindications to job placement) include a history and other findings consistent with diseases of the eyes, skin, or respiratory tract.

Periodic medical evaluations: Occupational health interviews and physical examinations should be performed at regular intervals during the employment period, as mandated by any applicable Federal, State, or local standard. Where no standard exists and the hazard is minimal, evaluations should be conducted every 3 to 5 years or as frequently as recommended by an experienced occupational health physician. Additional examinations may be necessary if a worker develops symptoms attributable to diazomethane exposure. The interviews, examinations, and medical screening tests should focus on identifying the adverse effects of diazomethane on the eyes, skin, or respiratory tract. Current health status should be compared with the baseline health status of the individual worker or with expected values for a suitable reference population.

Termination medical evaluations: The medical, environmental, and occupational history interviews, the physical examination, and selected physiologic or laboratory tests that were conducted at the time of placement should be repeated at the time of job transfer or termination to determine the worker's medical status at the end of his or her employment. Any changes in the worker's health status should be compared with those expected for a suitable reference population.

/SIGNS AND SYMPTOMS/ ON SKIN ... /IT/ CAUSES SEVERE, DELAYED INFLAMMATORY REACTION.

/SIGNS AND SYMPTOMS/ ... Inhalation can cause severe lung damage with symptoms of coughing, chest pain, shortness of breath, fever and fatigue. Exposure to the gas or liquid can cause severe skin burns and eye damage. Contact with liquid can cause frostbite.

/SIGNS AND SYMPTOMS/ The toxic effects of diazomethane advance insidiously. Diazomethane exposure has caused irritation of the eyes, dizziness, denudation of mucus membranes, and sensitization in laboratory workers. Chest pain, fever, and sever asthmatic attacks have been reported

/SIGNS AND SYMPTOMS/ Inhalation of diazomethane by man, depending on degree of exposure caused chest pains, asthmatic symptoms, cough and fever, fulminating pneumonia, moderate cyanosis, shock and death.

For more Human Toxicity Excerpts (Complete) data for DIAZOMETHANE (12 total), please visit the HSDB record page.

Diazomethane's production and use as a powerful methylating agent for acidic compounds such as carboxylic acids, phenols, enols(1) used in synthetic organic transformations may result in its release to the environment through various waste streams(SRC).

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Diazomethane is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b).