Sodium borohydride → 4-Cyclopentylbutan-1-ol

HRID 1071173노트

반응식

HRID 1071173 반응식
[CH:1]1([CH2:6][CH2:7][CH2:8][CH:9]=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>C(O)C>[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][OH:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 219320564-Cyclopentylbutanal

생성물 1

HCID 217976434-Cyclopentylbutan-1-ol수율 63%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Cyclopentyl-butyraldehyde (4.9 g, 35 mmol) was taken up in ethanol (100 mL) and treated slowly with sodium borohydride (1.72 g, 4.54 mmol). The reaction was stirred for three days and quenched with water (10 mL). The reaction was diluted with dichloromethane (200 mL) and washed with water (2×100 mL). The organic phase was dried (MgSO4), filtered, and concentrated to yield an oil. The product was passed through a pad of silica to yield 4-cyclopentyl-butan-1-ol as a colorless oil (3.12 g, 63%).

후처리

  1. customquenched with water (10 mL)
  2. additionThe reaction was diluted with dichloromethane (200 mL)
  3. washwashed with water (2×100 mL)
  4. dry with materialThe organic phase was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto yield an oil

출처 및 근거

ORD 기록
ord-1300ab512c8a4751bb1502d043ef4969
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903218B2

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