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Triphenylphosphine → 1-(4-Nitrophenyl)-4-(2-phenylsulfanylethyl)-1,4-dihydrotetrazol-5-one

HRID 1071175
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HRID 1071175 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14](=[O:15])[N:13]=[N:12][NH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:16]1([S:22][CH2:23][CH2:24]O)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14](=[O:15])[N:13]([CH2:24][CH2:23][S:22][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:12]=[N:11]2)=[CH:8][CH:9]=1)([O-:3])=[O:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 696852-(Phenylthio)ethanolHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 178518974HCID 178518974, 화합물

생성물 1

HCID 224717701-(4-Nitrophenyl)-4-(2-phenylsulfanylethyl)-1,4-dihydrotetrazol-5-one수율 90.5%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

1-(4-Nitrophenyl)-5-tetrazolone (Example 8) (153 mg, 0.74 mmol), 2-hydroxyethyl phenyl sulfide (0.1 mL, 0.74 mmol), and triphenylphosphine (194 mg, 0.74 mmol) were suspended in tetrahydrofuran (2.5 mL). Diethyl azodicarboxylate (0.12 mL, 0.74 mmol) was added dropwise. After 12 hours the mixture was concentrated in vacuo to an oil. Silica gel chromatography (9:1 hexane/ethyl acetate) afforded a solid (230 mg, 90%). 1H NMR (CDCl3, 300 MHz) δ 8.30 (d, 9.2 Hz, 2H), 8.13 (d, 9.2 Hz, 2H), 7.37 (d, 7.0 Hz, 2H), 7.20 (d, 7.0 Hz, 2H), 7.12 (m, 1H), 4.19 (t, 6.6 Hz, 2H), 3.32 (t, 6.6 Hz, 2H); MS (CI) m/z 344 (MH+).

후처리

  1. concentrationAfter 12 hours the mixture was concentrated in vacuo to an oil

출처 및 근거

ORD 기록
ord-adf84d60802e4270908755e3e12de3a7
출처 데이터셋
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06903218B2

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