Water → 4-Cyano-5-methyl-4-(3-thienyl)hexanol

HRID 1071636노트

반응식

HRID 1071636 반응식
O1CCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O.[C:15]([C:17]([C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)([CH:25]([CH3:27])[CH3:26])[CH2:18][CH2:19][C:20](OCC)=[O:21])#[N:16]>>[C:15]([C:17]([C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)([CH:25]([CH3:27])[CH3:26])[CH2:18][CH2:19][CH2:20][OH:21])#[N:16]

참가 물질

6

반응물 5

HCID 962WaterHCID 8028Tetrahydrofuran2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22393748Ethyl 4-cyano-5-methyl-4-(3-thienyl)hexanoate

생성물 1

HCID 223937214-Cyano-5-methyl-4-(3-thienyl)hexanol수율 95%

실험 절차

A tetrahydrofuran solution (35 ml) in which ethyl 4-cyano-5-methyl-4-(3-thienyl)hexanoate (6.66 g) was dissolved was added dropwise to a tetrahydrofuran solution (50 ml) of lithium aluminum hydride (686 mg). After stirring for 2 hours, 2N aqueous NaOH and water were added to treat the mixture, and the resulting precipitates were filtered. The resulting filtrate was evaporated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a yellow oil (5.30 g, 95%).

후처리

  1. additionto treat the mixture
  2. customthe resulting precipitates
  3. filtrationwere filtered
  4. customThe resulting filtrate was evaporated
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

출처 및 근거

ORD 기록
ord-329c02ab1fd942cdb911f787f77129d2
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06906072B1

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