Piperidine → 2-(4-Piperidinopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

HRID 1072052

반응식

Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1.[NH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.C(NCCCC)CCC>>[N:22]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:13]=[C:14]4[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]4[CH:21]=3)=[CH:8][CH:7]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

참가 물질

반응물 3

HCID 8082Piperidine

HCID 8148Dibutylamine

HCID 142014592-(4-Chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

생성물 1

HCID 99029712-(4-Piperidinopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

실험 절차

This compound was prepared according to the procedure described in Example 1 of U.S. Pat. No. 4,727,145 or J. Med. Chem. 188, 31, 2221 et seq., above using 2-(4-chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine and piperidine instead of 2-(4-chloropropoxyphenyl)-imidazo[1,2-a]pyridine and dibutylamine respectively. Analysis: Calc'd for C22H27N3O 3HCl 1H2O; C, 6.76; H, 55.41; N, 8.81. Found: C, 6.63; H, 55.02; N, 8.55.

후처리

customThis compound was prepared

출처 및 근거

ORD 기록: ord-e89ae07198ce4e6e831a5a288c6f9ae9
출처 데이터셋: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06908929B2

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