Benzyl Chloride → 4-Benzyloxy-3-methoxy-benzonitrile

HRID 1072412노트

반응식

HRID 1072412 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11].C([O-])([O-])=O.[K+].[K+].[CH2:18](Cl)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[CH2:18]([O:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 781354-Hydroxy-3-methoxybenzonitrile

생성물 1

HCID 7937714-Benzyloxy-3-methoxy-benzonitrile수율 88.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 4-hydroxy-3-methoxybenzonitrile (20.0 g, 134 mmol) in acetone (200 ml) were added K2CO3 (55.6 g, 402 mmol) and benzyl chloride (23.2 ml, 201 mmol). The resulting reaction mixture was refluxed overnight. After cooling to room temperature, acetone was removed by evaporation under reduced pressure and the residue was recrystallized to obtain 4-benzyloxy-3-methoxy-benzonitrile(28.5 g, 88%). Then, according to the similar procedure of Example 1, 7-(4-Benzyloxy-3-methoxy-phenyl)-5-ethylsulfanyl-imidazo[1,2-c]pyrimidine was prepared.

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas refluxed overnight
  3. customacetone was removed by evaporation under reduced pressure
  4. customthe residue was recrystallized

출처 및 근거

ORD 기록
ord-3a7adb79b0ed4d3c9ff73eb4e56fd08e
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911443B2

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