Toluene → N-heptafluorobutyryl N,N'-dimethylimidodicarbonimidic diamide

참여 물질

반응 단계

To a solution of metformin in dry toluene was slowly added heptafluorobutyric anhydride (1.2 equivalents) and stirred at ambient temperature for 4 hours. The reaction was terminated by addition of water and the reaction mixture was precipitated in acetone. The crude fluorinated metformin was chromatographed on silica gel, yielding N-heptafluorobutyryl N,N′-dimethylimidodicarbonimidic diamide.

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