N-3-(4-pentylphenyl)propylphthalimide → 3-(4-Pentylphenyl)propylamine

HRID 1072716노트

반응식

HRID 1072716 반응식
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH2:14][N:15]2C(=O)C3=CC=CC=C3C2=O)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]>C(O)C.[OH-].[Na+]>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][CH2:14][NH2:15])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

4

반응물 1

HCID 22387439N-3-(4-pentylphenyl)propylphthalimide

생성물 1

HCID 223875943-(4-Pentylphenyl)propylamine수율 53%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of N-3-(4-pentylphenyl)propylphthalimide (41.1 g, 123 mmol) and hydrazinemonohydrate (9.0 ml, 185 mmol) in ethanol (300 ml) was refluxed for 3 hours. The reaction mixture was dissolved in 5N aqueous sodium hydroxide and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate anhydride, and the organic layer was concentrated to give the object compound as an oily substance. 13.5 g, (yield 53%)

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate anhydride
  4. concentrationthe organic layer was concentrated
  5. customto give the object compound as an oily substance

출처 및 근거

ORD 기록
ord-9d5c4dc7bc1a49ae88ad3e74dd16d6ff
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911468B2

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