Hydrochloric Acid → HCID 10255676, 화합물

HRID 1072776노트

반응식

HRID 1072776 반응식
C[C@@H](N)C1C=CC=CC=1.C[C@@H](N)C1C=CC=CC=1.[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20].Cl>C(OCC)(=O)C>[N+:19]([CH2:22][C@:23]1([CH2:30][C:31]([OH:33])=[O:32])[CH2:29][C@@H:28]2[C@H:24]1[CH2:25][CH2:26][CH2:27]2)([O-:21])=[O:20]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6431891-Phenethylamine, (+)-HCID 10449552HCID 10449552, 화합물

생성물 1

HCID 10255676HCID 10255676, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The (R)-α-methylbenzylamine salt of the nitro acid from example 2 (5.0 g, 23.4 mmol) was added to a mixture of ethyl acetate (50 ml) and 2M hydrochloric acid (15 ml). The mixture was stirred vigorously for 3-4 minutes and the phases were separated. The organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml). The organic layer was separated and the solvent was removed in vacuo to give the title compound as a yellow oil, which rapidly crystallised on standing (3.49 g).

후처리

  1. customthe phases were separated
  2. washThe organic layer was further washed with 2M hydrochloric acid (15 ml) and demineralised water (15 ml)
  3. customThe organic layer was separated
  4. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-aa8c84ad00e142e4a0e8adf34372da1a
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911555B2

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