Sodium Hydroxide → HCID 22386610, 화합물

HRID 1072972노트

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HRID 1072972 반응식
C([O:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][CH2:15][N:16]1[C:23]([CH2:24][C:25]2[CH:30]=[C:29]([CH3:31])[CH:28]=[C:27]([CH3:32])[CH:26]=2)=[C:22]([CH2:33][CH3:34])[C:20](=[O:21])[NH:19][C:17]1=[O:18])(=O)C1C=CC=CC=1.[OH-].[Na+]>CO>[CH3:32][C:27]1[CH:26]=[C:25]([CH:30]=[C:29]([CH3:31])[CH:28]=1)[CH2:24][C:23]1[N:16]([CH2:15][O:14][CH2:13][CH2:12][CH2:11][CH2:10][OH:9])[C:17](=[O:18])[NH:19][C:20](=[O:21])[C:22]=1[CH2:33][CH3:34]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 397715HCID 397715, 화합물

생성물 1

HCID 22386610HCID 22386610, 화합물수율 48.8%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
20 °C

실험 절차

1-(4-benzoyloxybutyloxymethyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil (500 mg, 1.08 mmol) was added to a solution of sodium hydroxide (360 mg, 9 mmol) in methanol (50 ml) and the mixture was stirred at 20° C. for 3 h. After neutralization (concentrated hydrochloric acid) and concentration, the residue was subjected to a flash column chromatography (dichloromethane/methanol 19:1) which gave the 6-(3,5-dimethyl benzyl)-5-ethyl-1-(4-hydroxybutyloxymethyl)uracil (190 mg, 48%) in the form of a white solid.

후처리

  1. concentrationAfter neutralization (concentrated hydrochloric acid) and concentration

출처 및 근거

ORD 기록
ord-699a03f6197744fe88a304be0f6076f3
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911450B1

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