Benzyl carbamate → 2-(((Benzyloxy)carbonyl)amino)-2-hydroxyacetic acid

HRID 1072997노트

반응식

HRID 1072997 반응식
O.[C:2]([OH:6])(=[O:5])[CH:3]=[O:4].[C:7](=[O:17])([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:8]>CCOCC>[CH2:10]([O:9][C:7]([NH:8][CH:3]([OH:4])[C:2]([OH:6])=[O:5])=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 12136Benzyl carbamateHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 35095062-(((Benzyloxy)carbonyl)amino)-2-hydroxyacetic acid수율 47%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Glyoxylic acid monohydrate (20.3 g, 221 mmol) and benzyl carbamate (30.6 g, 202 mmol) are added to ether (200 mL). The solution is allowed to stir for 24 h at rt. The resulting thick precipitate is filtered, and the residue is washed with ether, affording ([(benzyloxy)carbonyl]amino)(hydroxy)acetic acid (C150) as a white solid (47% yield). MS (CI) for C10H11NO5+H m/z: 226 (M+H).

후처리

  1. filtrationThe resulting thick precipitate is filtered
  2. washthe residue is washed with ether

출처 및 근거

ORD 기록
ord-8f012c90dd214017baa728a2bda6b9cd
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911543B2

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