Sodium Hydroxide → Oleoyl lysophosphatidic acid

HRID 1073015노트

반응식

HRID 1073015 반응식
[Si]([O:18][CH:19]([CH2:41][O:42][P:43]([OH:46])([OH:45])=[O:44])[CH2:20][O:21][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[OH-].[Na+]>ClCCl>[OH:18][CH:19]([CH2:41][O:42][P:43]([OH:45])([OH:46])=[O:44])[CH2:20][O:21][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 69746178HCID 69746178, 화합물

생성물 1

HCID 5497152Oleoyl lysophosphatidic acid수율 78%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6 (1 mmol) is dissolved in 10 ml of dichloromethane, and 25 ml of a 1% methanolic NaOH solution is added. This is concentrated after 20 hours at room temperature, and the residue is acidified with 1N HCl. The mixture is extracted with ethyl acetate. The combined organic phases are washed with 20 ml of H2O and dried over MgSO4, filtrated and concentrated. The residue is treated with methanol. Yield: 78% of colorless crystals.

후처리

  1. concentrationThis is concentrated after 20 hours at room temperature
  2. extractionThe mixture is extracted with ethyl acetate
  3. washThe combined organic phases are washed with 20 ml of H2O
  4. dry with materialdried over MgSO4
  5. filtrationfiltrated
  6. concentrationconcentrated
  7. additionThe residue is treated with methanol

출처 및 근거

ORD 기록
ord-94d1932faa0b47f6a4cd044e07f3b95c
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06911553B1

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