(3-Butoxyphenyl)acetonitrile → HCID 22379525, 화합물

HRID 1073242노트

반응식

HRID 1073242 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[CH2:9][C:10]#[N:11])[CH2:2][CH2:3][CH3:4].[H][H]>[Ni].CO>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH2:9][CH2:10][NH2:11])[CH:12]=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 2

HCID 22158212(3-Butoxyphenyl)acetonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22379525HCID 22379525, 화합물수율 106.9%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

Raney nickel catalyst (approx 5 g) was added to a solution of 3-butyloxybenzyl cyanide (38.64 g, prepared according to example 1 D) in saturated ammoniacal methanol (700 cm3). The resulting mixture was heated at 70° C. in the presence of hydrogen (45 Atmospheres) for two hours and was then allowed to cool to room temperature overnight. The cooled mixture was filtered to remove the catalyst and was then evaporated down to give a green oil (42.2 g).

후처리

  1. filtrationThe cooled mixture was filtered
  2. customto remove the catalyst
  3. customwas then evaporated down

출처 및 근거

ORD 기록
ord-7253f6f586a5486c800e761f8ff6ab2a
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968698

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