Sodium Hydroxide → cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)

HRID 1073312노트

반응식

HRID 1073312 반응식
C([C@H]([C@@H](C(O)=O)O)O)(O)=O.[NH2:11][C@@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@@H:13]1[C@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 15107948(3R)-3-Aminopyrrolidine D(-)-tartrateHCID 86744074platinum (II) potassium chloride

생성물 1

HCID 18640044cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)수율 57.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

(3R)-3-Aminopyrrolidine D(-)-tartrate (236 mg) prepared in Reference Example 1-(1) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) (200 mg) as pale yellow crystal.

후처리

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

출처 및 근거

ORD 기록
ord-4169bbb3c4154d2ba7bf6498c53b602a
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968800

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