Sodium Hydroxide → HCID 18640048, 화합물

HRID 1073314노트

반응식

HRID 1073314 반응식
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][C@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@H:13]1[C@@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 86744074platinum (II) potassium chlorideHCID 86744075HCID 86744075, 화합물

생성물 1

HCID 18640048HCID 18640048, 화합물수율 63.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

(3S)-3-Aminopyrrolidine L(+)-tartrate (236 mg) prepared in Reference Example 1-(2) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated to dryness under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3S)-3-aminopyrrolidine platinum (II) (221 mg) as pale yellow crystal.

후처리

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated to dryness under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

출처 및 근거

ORD 기록
ord-bfa27fc0ea7b4abb8b60697e553fe70d
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968800

반응 노트

불러오는 중…