4-(Trifluoromethyl)benzoic acid → 4-(Trifluoromethyl)benzoyl bromide

반응식

[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.P(Br)(Br)[Br:15]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([Br:15])=[O:8])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 99664-(Trifluoromethyl)benzoic acid

HCID 24614Phosphorus tribromide

생성물 1

HCID 141533934-(Trifluoromethyl)benzoyl bromide수율 169.7%

실험 절차

In a 50 ml glass reactor, 30 g of 4-trifluoromethylbenzoic acid and 14.5 g of phosphorus tribromide were reacted at 155° C. for 3 hr. After that the reaction liquid was distilled under reduced pressure to obtain 23 g of 4-trifluoromethylbenzoyl bromide having a boiling point of 88°-89° C. at 18 mmHg. The yield in this reaction was 58%.

후처리

customAfter that the reaction liquid
distillationwas distilled under reduced pressure

출처 및 근거

ORD 기록: ord-37debe9c721a41708dc79f130d3dd352
출처 데이터셋: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04968852

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