Diazomethane → Methyl 2-bromo-delta-oxobenzenepentanoate

HRID 1073566노트

반응식

HRID 1073566 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13].[N+](=[CH2:18])=[N-]>CCOCC>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][CH2:10][CH2:11][C:12]([O:14][CH3:18])=[O:13]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 147984685-(2-Bromophenyl)-5-oxovaleric acid

생성물 1

HCID 14582851Methyl 2-bromo-delta-oxobenzenepentanoate수율 97%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 0.54 g (2.0 mmol) of the product of Example 2 dissolved in ether was added an ethereal solution of excess diazomethane at 0° C. to produce a 97% yield of the ester as a yellow oil. The ester was used without further purification.

출처 및 근거

ORD 기록
ord-9237a7581eb14403b63404293bbd7d96
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04970229

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