3-Formylbenzamidine hydrochloride → HCID 178478849, 화합물

HRID 1073843노트

반응식

HRID 1073843 반응식
C1(C)C(S(O)(=O)=O)=CC=CC=1.[NH2:12][NH:13][C:14]([NH:16][OH:17])=[NH:15].[ClH:18].[CH:19]([C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24]([NH2:26])=[NH:25])=O>O.Cl.CO>[ClH:18].[ClH:18].[OH:17][NH:16][C:14]([NH:13][N:12]=[CH:19][C:21]1[CH:29]=[CH:28][CH:27]=[C:23]([C:24](=[NH:25])[NH2:26])[CH:22]=1)=[NH:15]

참가 물질

6

반응물 2

HCID 27592083-Formylbenzamidine hydrochlorideHCID 178424425HCID 178424425, 화합물

생성물 1

HCID 178478849HCID 178478849, 화합물

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 7.3 g (0.028 mol) of 1-amino-3-hydroxyguanidine toluenesulfonate in 14 ml of water and 14.5 ml of 2N hydrochloric acid is added to a solution of 6.9 g (0.028 mol) of crude 3-formylbenzamidine hydrochloride (prepared as described in Example 1b) in 28 ml of methanol, and the reaction mixture is heated at 70° for 1 hour. It is then cooled and concentrated by evaporation, and the crude product is recrystallised from water/ethanol; m.p. 248°-250°.

후처리

  1. temperaturethe reaction mixture is heated at 70° for 1 hour
  2. temperatureIt is then cooled
  3. concentrationconcentrated by evaporation
  4. customthe crude product is recrystallised from water/ethanol

출처 및 근거

ORD 기록
ord-62c889033ffd432fb2cf05f623766aa2
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971986

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