Ethylene carbonate → 2-(5-Fluoro-2-methoxyphenoxy)ethanol
반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.C1(=O)O[CH2:14][CH2:13][O:12]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][CH2:14][CH2:13][OH:12]참가 물질
6
실험 절차
A suspension of 8.75 g of 5-fluoro-2-methoxyphenol, 10.9 g of ethylene carbonate and 8.50 g of potassium carbonate in 12 ml of toluene was refluxed for 2.5 hours. The reaction mixture was diluted with benzene, washed with water, dried and evaporated. The residue was distilled to give 9.15 g of 2-(5-fluoro-2-methoxyphenoxy)ethanol as colorless oil, b.p. 138°-140° C. (8mmHg).
후처리
- temperaturewas refluxed for 2.5 hours
- washwashed with water
- customdried
- customevaporated
- distillationThe residue was distilled
출처 및 근거
- ORD 기록
- ord-b9a9945b2083473f800340acad563587
- 출처 데이터셋
- uspto-grants-1990_11
- 특허 번호
- US04971990
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