Hydrazine hydrate (1:1) → HCID 11159719, 화합물

HRID 1073853노트

반응식

HRID 1073853 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[O:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.O.NN>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[O:7][CH2:8][CH2:9][NH2:10]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 22157077HCID 22157077, 화합물

생성물 1

HCID 11159719HCID 11159719, 화합물수율 64.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 10.0 g of N-[2-(5-fluoro-2-methoxyphenoxy)ethyl]phthalimide and 5.14 ml 5.14 ml of hydrazine hydrate in 100 ml of ethanol was heated for 1 hour at 50°-60° C. After cooling, the precipitate was filtered off and the filtrate was evaporated. The residue was diluted with water and extracted with chloroform. The extract was washed with water, dried and evaporated. The residue was distilled to give 3.81 g of the desired compound as a colorless oil, b.p. 126°-127° C. (9 mmHg).

후처리

  1. temperaturewas heated for 1 hour at 50°-60° C
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. customthe filtrate was evaporated
  5. additionThe residue was diluted with water
  6. extractionextracted with chloroform
  7. washThe extract was washed with water
  8. customdried
  9. customevaporated
  10. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-1ce6df1f218d486a88a2077d4b7debdc
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971990

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