Sodium borohydride → HCID 19895686, 화합물

HRID 1073953

반응식

HRID 1073953 반응식
[BH4-].[Na+].[OH:3][C:4](=[CH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][N:19]=1)[C:5]([CH3:16])([CH3:15])[O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>C(O)C>[OH:3][CH:4]([CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][N:19]=1)[C:5]([CH3:15])([CH3:16])[O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]#[N:12])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 1364045254-[2-Hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)-2-propenyloxy]benzonitrile

생성물 1

HCID 19895686HCID 19895686, 화합물수율 73,959.797%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
20 °C

실험 절차

0.013 mg of sodium borohydride was added to a solution of 0.098 mg of 4-[2-hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)-2-propenyloxy]benzonitrile in 3 ml of ethanol and the solution was stirred at 20° C. for 16 hours. The solvent was removed by evaporation and the residue was partitioned between ethyl acetate and water. The organic phase was evaporated and the residue was chromatographed on silica gel using ethyl acetate for the elution. There was obtained 0.073 g of 4-[2-hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)propoxy]benzonitrile in the form of a white solid of melting point 96°-98° C.

후처리

  1. customThe solvent was removed by evaporation
  2. customthe residue was partitioned between ethyl acetate and water
  3. customThe organic phase was evaporated
  4. customthe residue was chromatographed on silica gel
  5. washfor the elution

출처 및 근거

ORD 기록
ord-043738df25ec4b82aaf4257a235dcd73
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971982

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