Sodium borohydride → 4-[2-Hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile

HRID 1073958노트

반응식

HRID 1073958 반응식
[BH4-].[Na+].[CH3:3][C:4]([CH3:23])([O:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1)[C:5](=[O:13])[CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1>C(O)C.O>[OH:13][CH:5]([CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)[C:4]([CH3:3])([CH3:23])[O:14][C:15]1[CH:16]=[CH:17][C:18]([C:19]#[N:20])=[CH:21][CH:22]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 198956054-[1,1-Dimethyl-2-oxo-3-(2-pyrazinyl)propoxy]benzonitrile

생성물 1

HCID 198956134-[2-Hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile수율 62.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
20 °C

실험 절차

0.107 g of sodium borohydride was added to a stirred suspension of 0.79 g of 4-[1,1-dimethyl-2-oxo-3-(2-pyrazinyl)propoxy]benzonitrile in 20 ml of ethanol. The mixture was stirred at 20° C. for 1.5 hours and was then diluted with water. The solution was extracted with ethyl acetate and the organic phase was then washed with sodium chloride solution and evaporated to give 0.5 g of 4-[2-hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile in the form of a white solid of melting point 94°-95° C. (from diethyl ether).

후처리

  1. extractionThe solution was extracted with ethyl acetate
  2. washthe organic phase was then washed with sodium chloride solution
  3. customevaporated

출처 및 근거

ORD 기록
ord-3a7f10286aca492d95da22c3a618a741
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971982

반응 노트

불러오는 중…