Hydrochloric Acid → L-isoleucyl-L-proline benzylester hydrochloride

HRID 1073997노트

반응식

HRID 1073997 반응식
[CH2:1]([O:8][C:9](=[O:30])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH:17]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>O1CCOCC1.C(OCC)C>[ClH:31].[CH2:1]([O:8][C:9](=[O:30])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH2:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 14306235Boc-Ile-Pro-OBzl

생성물 1

HCID 14306240L-isoleucyl-L-proline benzylester hydrochloride수율 92.9%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

N-t-butyloxycarbonyl-L-isoleucyl-L-proline benzylester (39.76 g, 95 mmole) was dissolved in 4N hydrochloric acid in dioxane (360 ml), and stirred for 30 minutes at room temperature. The solvent was distilled and the residue thus obtained was powdered in diethyl ether to obtain L-isoleucyl-L-proline benzylester hydrochloride(yield: 31.31 g, 92.9%).

후처리

  1. distillationThe solvent was distilled
  2. customthe residue thus obtained

출처 및 근거

ORD 기록
ord-2bb9f746c0874a6a9cb3d38a698c4c84
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971993

반응 노트

불러오는 중…