o-Xylyl bromide → Ethyl (2-methylbenzylthio)acetate

HRID 1074076

반응식

HRID 1074076 반응식
C[C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.Br[CH2:17]C1C=CC=CC=1C.CC[O-].[Na+].SCC(OCC)=O>C(O)C>[CH3:17][C:4]1[CH:3]=[CH:2][CH:15]=[CH:14][C:5]=1[CH2:6][S:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

6

반응물 4

HCID 6992o-Xylyl bromideHCID 12185Ethyl ThioglycolateHCID 2723922Sodium ethoxideHCID 4107274Ethyl (4-methylbenzylthio)acetate

생성물 1

HCID 13245059Ethyl (2-methylbenzylthio)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 2-bromomethyltoluene (10 g), a 2M ethanolic solution of sodium ethylate (30 cc) and ethyl 2-mercaptoacetate (6.5 g), in ethanol (100 cc). Ethyl (2-methylbenzylthio)acetate (8.9 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.

출처 및 근거

ORD 기록
ord-8be7b2a72c794538966f31b125c630d7
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04971979

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