Phenacyl bromide → (2-Oxo-2-phenylethyl)(triphenyl)phosphanium bromide

HRID 1074259노트

반응식

HRID 1074259 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[Br-:1].[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][P+:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 6259Phenacyl bromideHCID 11776Triphenylphosphine

생성물 1

HCID 197064(2-Oxo-2-phenylethyl)(triphenyl)phosphanium bromide수율 93.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

50.0 g. (251mmoles) of α-bromoacetophenone (Compound CI) and 65.9 g. (251 mmoles) of triphenylphosphine are stirred in 500 ml. of toluene at 20°-25° C. under nitrogen for 16 hours, and the resulting solid is collected by filtration, rinsed with toluene and rinsed with diethyl ether to obtain the product as a white powder (107.98 g. (93%)).

후처리

  1. filtrationthe resulting solid is collected by filtration
  2. washrinsed with toluene
  3. washrinsed with diethyl ether

출처 및 근거

ORD 기록
ord-326ceb0eb86c41169175edd1c1c7e54f
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04973704

반응 노트

불러오는 중…