Hydrochloric Acid → 2-(2-Aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride

HRID 1074347노트

반응식

HRID 1074347 반응식
[CH:1]1([O:4][N:5]=[C:6]([C:10]2[N:11]=[C:12]([NH:15]C=O)[S:13][CH:14]=2)[C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[NH2:15][C:12]1[S:13][CH:14]=[C:10]([C:6](=[N:5][O:4][CH:1]2[CH2:3][CH2:2]2)[C:7]([OH:9])=[O:8])[N:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 540072742-Cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetic acid

생성물 1

HCID 867443572-(2-Aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl) acetic acid (syn isomer) (255 mg) and conc. hydrochloric acid (0.21 ml) in methanol (1.3 ml) was stirred at 30° to 32° C. for 1.5 hours. The mixture was concentrated in vacuo, triturated with diisopropyl ether, diethyl ether and ethyl acetate in turn. The resultant solid was dried over phosphorus pentoxide to give 2-(2-aminothiazol-4-yl)-2-cyclopropyloxyiminoacetic acid hydrochloride (syn isomer) (265 mg).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customtriturated with diisopropyl ether, diethyl ether and ethyl acetate in turn
  3. dry with materialThe resultant solid was dried over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-926525e67b2a4b009b8403c89e8d83ba
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04973699

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