Hydrochloric Acid → Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

HRID 1074373노트

반응식

HRID 1074373 반응식
C([NH:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O-:20])=[O:19])(=[O:8])=[O:7])(C)(C)C.Cl.[CH3:22]O>>[NH2:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O:20][CH3:22])=[O:19])(=[O:8])=[O:7]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 867389413-Tert-butylaminosulfonylbenzothiophene-2-carboxylate

생성물 1

HCID 13178321Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

실험 절차

A solution of 6 g of 3-tert-butylaminosulfonylbenzothiophene-2-carboxylate acid in 100 ml of methanol was saturated with anhydrous hydrogen chloride and then heated to reflux for three hours. The mixture was evaporated in vacuo to half of its volume and the residue poured into 200 g of ice and filtered to yield the desired product melting at 150°-154°. The infrared absorption spectrum shown by this material was qualitatively equivalent to that of the product of Example 4.

후처리

  1. temperatureheated
  2. temperatureto reflux for three hours
  3. customThe mixture was evaporated in vacuo to half of its volume
  4. additionthe residue poured into 200 g of ice
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-e853363dd4d946f4908ab3b7e0dc3837
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04391627

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