Pyrrolidine → 6-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074391노트

반응식

HRID 1074391 반응식
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

생성물 1

HCID 131789766-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

실험 절차

A mixture was prepared by adding 4.5 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine to 8.7 g of pyrrolidine and this was heated at reflux for 6.5 hours during which time the mixture turned brown. The reaction mixture was then poured into about 150 ml of ice water. A solid formed immediately and this was separated by filtration and air dried to give 6-(1-pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 128° C.

후처리

  1. customA mixture was prepared
  2. temperaturethis was heated
  3. temperatureat reflux for 6.5 hours during which time the mixture
  4. customA solid formed immediately
  5. customthis was separated by filtration and air
  6. customdried

출처 및 근거

ORD 기록
ord-3d058b71237d4773ac9fe46eeb6fab86
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04391807

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