1-Methylpiperazine → 6-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074393노트

반응식

HRID 1074393 반응식
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:18][CH2:17]1

참가 물질

3

반응물 2

HCID 531671-MethylpiperazineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

생성물 1

HCID 131789786-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

실험 절차

A mixture of 15 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine and 36.2 g of 1-methylpiperazine was heated at reflux for 48 hours during which time the reaction mixture turned brown. The reaction was poured into about 150 ml of ice water. The solid which formed was separated by filtration and air-dried to give 6-(4-methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 79.5° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 48 hours during which time the reaction mixture
  3. customThe solid which formed
  4. customwas separated by filtration
  5. customair-dried

출처 및 근거

ORD 기록
ord-8d2f3a9a111541c88a29b7a49eca0cdd
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04391807

반응 노트

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