HCID 12833268, 화합물 → 1-(3'-Amino-4',6'-dimethylphenyl)azetidin-2-one

HRID 1074852노트

반응식

HRID 1074852 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([N:12]2[CH2:15][CH2:14][C:13]2=[O:16])[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([N:12]2[CH2:15][CH2:14][C:13]2=[O:16])[C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10]

참가 물질

4

반응물 1

HCID 12833268HCID 12833268, 화합물

생성물 1

HCID 128332701-(3'-Amino-4',6'-dimethylphenyl)azetidin-2-one수율 90.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

21.2 g (0.0965 mol) of the 1-(3'-nitro-4',6'-dimethylphenyl)-azetidin-2-one obtained according to a) are hydrogenated in 210 ml of methanol with 2 g of Raney nickel at 30°-35° under normal pressure. The reaction solution is filtered and evaporated. Recrystallisation of the crude product from methanol gives 16.6 g (90%) of crystals having a melting point of 123°-124°.

후처리

  1. filtrationThe reaction solution is filtered
  2. customevaporated
  3. customRecrystallisation of the crude product from methanol

출처 및 근거

ORD 기록
ord-3f11ea2e6cfc4a61bc338740ae7d96d3
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394156

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