Sodium Hydroxide → 1-(3-Amino-4',6'-dichlorophenyl)-pyrrolidin-2-one
반응식
[NH2:1][C:2]1[CH:3]=[C:4]([NH:10][C:11](=[O:16])[CH2:12][CH2:13][CH2:14]Cl)[C:5]([Cl:9])=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:16])[C:5]([Cl:9])=[CH:6][C:7]=1[Cl:8]참가 물질
4
실험 절차
13.5 g (0.05 mol) of N-(3-amino-4,6-dichlorophenyl)-γ-chlorobutyramide, 200 ml of tetrahydrofurane and 100 ml of 1 N NaOH solution are stirred for 5 hours at 50° C. After the mixture has been allowed to cool, it is extracted three times with 300 ml of ethyl acetate and the extracts are washed with water, dried with magnesium sulphate and concentrated. The resulting product is recrystallised from toluene/ethyl acetate. Yield: 8.5 g; melting point 168°-170° C.
후처리
- temperatureto cool
- extractionit is extracted three times with 300 ml of ethyl acetate
- washthe extracts are washed with water
- dry with materialdried with magnesium sulphate
- concentrationconcentrated
- customThe resulting product is recrystallised from toluene/ethyl acetate
출처 및 근거
- ORD 기록
- ord-4b0196f73fca4349a1b6f5d5bc29c5ca
- 출처 데이터셋
- uspto-grants-1983_07
- 특허 번호
- US04394156
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