1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one → 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

HRID 1074894

반응식

HRID 1074894 반응식
[N:1]1([CH2:6][C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[O:8])[CH:5]=[N:4][CH:3]=[N:2]1.[BH4-].[Na+]>CO>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH:7]([OH:8])[CH2:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 7164721-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-oneHCID 4311764Sodium borohydride

생성물 1

HCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of α-1,2,4-triazol-1-yl-p-chloroacetophenone (4 g) in methanol (12 ml) was treated with sodium borohydride (0.5 g) with cooling and stirring. The mixture was then left at room temperature for 0.5 hour and refluxed for 1 hour. The methanol was removed under reduced pressure and water (25 ml) was added followed by dilute hydrochloric acid (10 ml). The white solid was filtered, washed with water and dried. Crystallisation from ethyl acetate-petroleum ether (60°-80°) gave the title compound as a white crystalline solid. Analysis:

후처리

  1. temperaturewith cooling
  2. temperaturerefluxed for 1 hour
  3. customThe methanol was removed under reduced pressure and water (25 ml)
  4. additionwas added
  5. filtrationThe white solid was filtered
  6. washwashed with water
  7. customdried
  8. customCrystallisation from ethyl acetate-petroleum ether (60°-80°)

출처 및 근거

ORD 기록
ord-aec6030bdd3e4464948156ea7dbc710f
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394380

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