Cysteamine Hydrochloride → HCID 15592302, 화합물

HRID 1075077

반응식

HRID 1075077 반응식
Cl.[NH2:2][CH2:3][CH2:4][SH:5].C[O-].[Na+].Cl[CH2:10][C:11]1[N:15]=[C:14]([CH3:16])[O:13][N:12]=1>CO>[CH3:16][C:14]1[O:13][N:12]=[C:11]([CH2:10][S:5][CH2:4][CH2:3][NH2:2])[N:15]=1

참가 물질

5

반응물 3

HCID 9082Cysteamine HydrochlorideHCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 10942334Sodium Methoxide

생성물 1

HCID 15592302HCID 15592302, 화합물수율 121.9%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Cysteamine hydrochloride (3.03 g; 26.7 mmoles) was added in several portions over a period of 10 minutes to a stirred solution of sodium methylate (2.89 g; 53.4 mmoles) in 50 ml of methanol at 0°. After stirring for 70 minutes at 0°, a solution of 3-chloromethyl-5-methyl-1,2,4-oxadiazole (3.54 g; 26.7 mmoles) in 15 ml of methanol was added dropwise over a period of 15 minutes, and the reaction mixture was allowed to stir at ambient temperature for 16 hours. The mixture was filtered, evaporated and redissolved in isopropyl alcohol, then filtered and evaporated under reduced pressure to give the title compound (5.64 g) as a yellow oil. The NMR spectrum (60 MHz) in CDCl3 gave the following resonances δ: 3.77 (s, 2H); 2.77 (m, 4H); 2.63 (s, 3H).

후처리

  1. stirringto stir at ambient temperature for 16 hours
  2. filtrationThe mixture was filtered
  3. customevaporated
  4. dissolutionredissolved in isopropyl alcohol
  5. filtrationfiltered
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-bbce1a95f8ca40b4a134bbc7e1a36c13
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04394508

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