Cysteamine Hydrochloride

HCID 9082CAS 156-57-0

부분 구조 검색 유사 구조 찾기

기본 정보

표준 SMILES: Cl.NCCS
InChIKey: OGMADIBCHLQMIP-UHFFFAOYSA-N
분자식: C2H7NS.ClH
평균 분자량: 113.61 g/mol
단동위원소 질량: 113.00659794

개요

Cysteamine hydrochloride is an alkanethiol.

이름 및 식별자

우선 이름: Cysteamine Hydrochloride
IUPAC: 2-aminoethanethiol;hydrochloride

이름 및 동의어

Cysteamine hydrochloride156-57-02-Aminoethanethiol hydrochlorideCysteamine HClMercaptamine hydrochlorideCysteaminium chlorideBekaptanETHANETHIOL, 2-AMINO-, HYDROCHLORIDEMercaptoethylamine hydrochlorideMerkamin hydrochlorideMercamine hydrochlorideCysteamine chlorohydrate

이름 더 보기

CysteaminhydrochloridCystaranDTXSID8045779IF1B771SVBNSC-758692CI-9148CYSTADROPSNSC-21116

데이터베이스 식별자

CAS: 156-57-0、16904-32-8
PubChem CID: 9082
DTXSID: DTXSID8045779
ChEMBL: CHEMBL1256137
ChEBI: CHEBI:201814
UNII: IF1B771SVB
EC Number: 205-858-1

물성

구조 계산 물성

극성 표면적: 27 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 2
회전 가능 결합 수: 1
무거운 원자 수: 5
형식 전하: 0
복잡도: 10

실험 및 물리화학적 성질

Chemical ClassesBiological Agents -> Amino Acids and Derivatives

CosmeticsReducing; Antioxidant

Solubility>17 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 3건

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine (Orphan designations)

FDA approved drugs -> Active ingredient

Physical DescriptionSolid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.

Warning

H302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 3건

Chemical: Ethanethiol, 2-amino-, hydrochloride

Status: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700

Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1건

Causes burns to skin and eyes; A respiratory tract irritant; [ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicity; Developmental toxicity observed in intraperitoneal study of mice; [Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]

Hazard Classes and CategoriesAcute Tox. 4 (92.1%)

독성 정보

Adverse EffectsDermatotoxin - Skin burns.

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

CYSTEAMINE HYDROCHLORIDE

Cystine Disulfide Reduction [MoA]; Cystine Depleting Agent [EPC]

MeSH Pharmacological ClassificationCompounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.

용도 및 제조

Uses · 1건

Cysteamine is a natural antioxidant, precursor in taurine biosynthesis, and component of coenzyme A; Used in medical research (potent ulcerogen), as a drug (nephropathic cystinosis), and antidote (acetaminophen poisoning); [Merck Index] A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [ChemIDplus] Used as an intermediate; [ECHA REACH Registrations]

Use ClassificationCosmetics -> Reducing; Antioxidant

General Manufacturing InformationEthanethiol, 2-amino-, hydrochloride (1:1): ACTIVE