2-멜캅토에틸아민 수화염화물
Cysteamine Hydrochloride
데이터를 보충하는 중입니다. 잠시 후 페이지를 새로 고치면 최신 내용을 볼 수 있습니다
기본 정보
- CAS
156-57-0- 표준 SMILES
Cl.NCCS- InChIKey
OGMADIBCHLQMIP-UHFFFAOYSA-N- 분자식
- C2H7NS.ClH
- 평균 분자량
- 113.61 g/mol
- 단동위원소 질량
- 113.00659794
개요
Cysteamine hydrochloride is an alkanethiol.
이름 및 식별자
- 우선 이름
- Cysteamine Hydrochloride
- IUPAC
- 2-aminoethanethiol;hydrochloride
- 현지명
- 2-멜캅토에틸아민 수화염화물
- 영어명
- Cysteamine hydrochloride
- 분자식
- C2H8ClNS
- 분자량
- 113.61
이름 및 동의어
Cysteamine hydrochloride156-57-02-Aminoethanethiol hydrochlorideCysteamine HClMercaptamine hydrochlorideCysteaminium chlorideBekaptanETHANETHIOL, 2-AMINO-, HYDROCHLORIDEMercaptoethylamine hydrochlorideMerkamin hydrochlorideMercamine hydrochlorideCysteamine chlorohydrate
이름 더 보기
2-멜캅토에틸아민수화염화물2-멜캅토에틸아민수화염화물시스테아민에이치씨엘2-MERCAPTOETHYLAMINE HYDROCHLORIDE2-AMINOETHANE-1-THIOL HYDROCHLORIDEAminoethanethiol hydrochloridemercaptoethylammonium chloride2-Mercaptoethylammonium chlorideL-Cysteamine hydrochloride2-AMINOETHANETHIOL HCL
CysteaminhydrochloridCystaranDTXSID8045779IF1B771SVBNSC-758692CI-9148CYSTADROPSNSC-21116
데이터베이스 식별자
- CAS
156-57-0、16904-32-8- PubChem CID
- 9082
- DTXSID
DTXSID8045779- ChEMBL
CHEMBL1256137- ChEBI
CHEBI:201814- UNII
- IF1B771SVB
- EC Number
- 205-858-1
물성
구조 계산 물성보충 중
- 극성 표면적
- 27 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 5
- 형식 전하
- 0
- 복잡도
- 10
실험 및 물리화학적 성질
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
CosmeticsReducing; Antioxidant
Solubility>17 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine (Orphan designations)
FDA approved drugs -> Active ingredient
Physical DescriptionSolid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]
물리화학적 성질
- 녹는점
- 67 · 67-71 °C
- 끓는 점
- 238.5 ℃[at · 238.5℃[at 101 325 Pa]
- 밀도
- 0.75 · 0.75
- 증기압
- 5.333 Pa · 5.333Pa at 25℃
- 굴절률
- 1.61 · 1.6100 (estimate)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 1 M at 20 °C, 투명, 무색
- 물리적 상태
- 결정질 분말 또는 펠렛
- 색상
- 하얀색
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.
Warning
H302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: Ethanethiol, 2-amino-, hydrochloride
Status: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700
Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Causes burns to skin and eyes; A respiratory tract irritant; [ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicity; Developmental toxicity observed in intraperitoneal study of mice; [Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (92.1%)
독성 정보
Adverse EffectsDermatotoxin - Skin burns.
안전 데이터
- wgk
- 3
- tsca
화학 및 산업
약리 정보
FDA Pharmacological Classification
CYSTEAMINE HYDROCHLORIDE
Cystine Disulfide Reduction [MoA]; Cystine Depleting Agent [EPC]
MeSH Pharmacological ClassificationCompounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.
용도 및 제조
Uses
Cysteamine is a natural antioxidant, precursor in taurine biosynthesis, and component of coenzyme A; Used in medical research (potent ulcerogen), as a drug (nephropathic cystinosis), and antidote (acetaminophen poisoning); [Merck Index] A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [ChemIDplus] Used as an intermediate; [ECHA REACH Registrations]
Use ClassificationCosmetics -> Reducing; Antioxidant
General Manufacturing InformationEthanethiol, 2-amino-, hydrochloride (1:1): ACTIVE
응용 분야
개요Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
용도Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
관련 반응
610건
화합물 노트
불러오는 중…