Chloroacetic Acid → HCID 20494284, 화합물

HRID 1075171노트

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HRID 1075171 반응식
[CH3:1][S:2][C:3]1[C:8]([F:9])=[CH:7][NH:6][C:5](=[O:10])[N:4]=1.Cl[CH2:12][C:13]([OH:15])=[O:14]>[OH-].[K+]>[C:13]([CH2:12][N:6]1[CH:7]=[C:8]([F:9])[C:3]([S:2][CH3:1])=[N:4][C:5]1=[O:10])([OH:15])=[O:14]

참가 물질

4

반응물 2

HCID 300Chloroacetic AcidHCID 178503576HCID 178503576, 화합물

생성물 1

HCID 20494284HCID 20494284, 화합물수율 36%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

4-Methylthio-5-fluoropyrimid-2-one (0.01 mol) was added to 2 M potassium hydroxide solution (10 ml) and dissolved. Chloroacetic acid (0.01 mol) was then added and the reaction mixture heated under reflux for 60 min when the pH was close to neutral. Some precipitate was removed by filtration from the cold reaction mixture and the filtrate brought to pH 2 with HCl. The precipitated product was recrystallised from aqueous methanol; yield 36%, m.p. 244°-245° C.

후처리

  1. dissolutiondissolved
  2. temperaturethe reaction mixture heated
  3. temperatureunder reflux for 60 min when the pH
  4. customwas close to neutral
  5. customSome precipitate was removed by filtration from the cold reaction mixture
  6. customThe precipitated product was recrystallised from aqueous methanol

출처 및 근거

ORD 기록
ord-eb152c87e3fd4b6ab693ea0ec91f96af
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395406

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