Acetic Anhydride → Methyl 4-formamidopyridine-2-carboxylate

HRID 1075258

반응식

HRID 1075258 반응식
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([O:17][CH3:18])=[O:16])[CH:10]=1>C(O)=O>[CH:1]([NH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([O:17][CH3:18])=[O:16])[CH:10]=1)=[O:3]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 3759117Methyl 4-aminopyridine-2-carboxylate

생성물 1

HCID 13060165Methyl 4-formamidopyridine-2-carboxylate수율 63.7%

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
50 °C

실험 절차

A mixture of formic acid (20 g.) and acetic anhydride (41.3 g.) was stirred for 30 minutes at 50° C. and thereto was added methyl 4-amino-2-pyridinecarboxylate (11 g.) at ambient temperature, and then the mixture was stirred for 2 hours at 70°-75° C. After the removal of the solvent from the reaction mixture, the residue was recrystallized from ethanol (160 ml.) to give a pale yellow powder of methyl 4-formamido-2-pyridinecarboxylate (8.3 g.), mp. 185° to 186.5° C.

후처리

  1. stirringthe mixture was stirred for 2 hours at 70°-75° C
  2. customAfter the removal of the solvent from the reaction mixture
  3. customthe residue was recrystallized from ethanol (160 ml.)

출처 및 근거

ORD 기록
ord-3a2ffe9d3883445f859794322cdea00b
출처 데이터셋
uspto-grants-1983_07
특허 번호
US04395411

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