Methanol → (3-Chloropropyl)octadecyldimethylammonium bromide

HRID 1075405노트

반응식

HRID 1075405 반응식
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH3:3].[Br:22][CH2:23][CH2:24][CH2:25][Cl:26].CO>CC(CC)=O>[Br-:22].[Cl:26][CH2:25][CH2:24][CH2:23][N+:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])([CH3:1])[CH3:3]

참가 물질

5

반응물 3

HCID 887MethanolHCID 80061-Bromo-3-chloropropaneHCID 15365Dimethyloctadecylamine

생성물 1

HCID 11037795(3-Chloropropyl)octadecyldimethylammonium bromide

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

반응 조건

온도
65 °C

실험 절차

A 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged with N,N-dimethyloctadecylamine (301.0 grams, 1.01 moles), 1-bromo-3-chloropropane (1700 grams, 1.08 moles) and methanol (200 mL). The reaction was maintained at 65° C. for 18 hours. Solvent was removed by rotary evaporation under reduced pressure to yield clear oil. The oil was transferred to a beaker containing methylethylketone (250 mL) causing a white precipitate to form. Solid material was collected by vacuum filtration, resuspended in methylethylketone (250 mL) and collected by vacuum filtration an additional two times. The solid was placed in a vacuum oven at 30° C. overnight. Yield 274.9 grams (0.59 moles, 58%).

후처리

  1. customA 1000 mL, round-bottomed flask equipped with air condensers
  2. customSolvent was removed by rotary evaporation under reduced pressure
  3. customto yield clear oil
  4. customto form
  5. filtrationSolid material was collected by vacuum filtration
  6. filtrationcollected by vacuum filtration an additional two times

출처 및 근거

ORD 기록
ord-e0bd1728d4704a6d8a1cf97aa5c12e2b
출처 데이터셋
uspto-grants-1999_05
특허 번호
US05900475

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