Methanol → (3-Chloropropyl)decyldimethylammonium bromide

HRID 1075406

반응식

HRID 1075406 반응식
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH3:3].[Br:14][CH2:15][CH2:16][CH2:17][Cl:18].CO>CCCCCC.C(OC)(C)(C)C>[Br-:14].[Cl:18][CH2:17][CH2:16][CH2:15][N+:2]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])([CH3:1])[CH3:3]

참가 물질

5

반응물 3

HCID 887MethanolHCID 80061-Bromo-3-chloropropaneHCID 70711N,N-Dimethyl-N-decylamine

생성물 1

HCID 85711137(3-Chloropropyl)decyldimethylammonium bromide

시약·촉매·용매 1

HCID 21982663Methyl t-butylether hexane용매

반응 조건

온도
65 °C

실험 절차

Into a 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged N,N-dimethyldecylamine (200.0 grams, 1.08 moles), 1-bromo-3-chloropropane (170 grams, 1.08 moles) and methanol (200 mL). The reaction was maintained at 65° C. for 18 hours. Solvent was removed by rotary evaporation under reduced pressure and furthermore with high vacuum distillation to yield brown oil. The oil was placed in a beaker and stirred with hexane/t-butylmethylether 1:1 solution (400 mL) causing a white precipitate The solids were collected by vacuum filtration. Solids were dried in a vacuum oven at 30° C. overnight. Yield 305.0 grams (0.089 moles, 82%).

후처리

  1. customInto a 1000 mL, round-bottomed flask equipped with air condensers
  2. customSolvent was removed by rotary evaporation under reduced pressure and furthermore with high vacuum distillation
  3. customto yield brown oil
  4. filtrationwere collected by vacuum filtration
  5. customSolids were dried in a vacuum oven at 30° C. overnight

출처 및 근거

ORD 기록
ord-18bc052603e840b1b7a696d1f0108c17
출처 데이터셋
uspto-grants-1999_05
특허 번호
US05900475

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