Sodium Chloride → 4-(Crotonoxymethyl)-4-ethyl-2-oxazolidinone

HRID 1075462

반응식

HRID 1075462 반응식
[CH2:1]([C:3]1([CH2:9][OH:10])[CH2:7][O:6][C:5](=[O:8])[NH:4]1)[CH3:2].[C:11](Cl)(=[O:15])/[CH:12]=[CH:13]/[CH3:14].[Na+].[Cl-]>C(Cl)(Cl)Cl>[C:11]([O:10][CH2:9][C:3]1([CH2:1][CH3:2])[CH2:7][O:6][C:5](=[O:8])[NH:4]1)(=[O:15])/[CH:12]=[CH:13]/[CH3:14]

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 643131trans-Crotonyl chlorideHCID 112635594-Ethyl-4-hydroxymethyl-2-oxazolidinone

생성물 1

HCID 184131814-(Crotonoxymethyl)-4-ethyl-2-oxazolidinone

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3.1 grams (0.021 mole) 4-ethyl-4-hydroxymethyl-2-oxazolidinone, prepared identically to that discussed in example 1, 2.3 grams (0.022 mole) trans-crotonyl chloride, and 25 milliliters chloroform were mixed in a one-necked round-bottom flask. The procedure employed was identical to that discussed in example 1. 4.20 grams (98 % of the yield theoretically expected) of pure product was obtained as a clear oil. The product exhibited the following spectral data: 1H NMR (CDCl3) δ0.90(t, 3H J=1.8 Hz), 1.48-1.67(m, 2H), 1.83(d, 3H J=3.6 Hz), 3.97-4.19(m, 4H), 5.79(d, 1H J=3.6 Hz), 6.90-6.99(m, 2H); 13C NMR (CDCl3) δ7.3, 18.1, 28.3, 60.2, 66.7, 70.9, 121.7, 146.3, 159.6, 166.0; IR (NaCl) 3229, 3020, 2960, 1780 cm-1 ; MS m/z 213. This monomer can be chlorinated or brominated by the same procedure as in example 1.

후처리

  1. additionwere mixed in a one-necked round-bottom flask
  2. custom4.20 grams (98 % of the yield theoretically
  3. customwas obtained as a clear oil

출처 및 근거

ORD 기록
ord-20d4f47aca12455d9778d38125570a49
출처 데이터셋
uspto-grants-1999_05
특허 번호
US05902818

연결된 노트

불러오는 중…