Dimethylformamide dimethyl acetal → 2-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

HRID 1075562노트

반응식

HRID 1075562 반응식
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C=O.C(N(CC)CC)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:8][C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=1

참가 물질

5

반응물 2

HCID 78373Dimethylformamide dimethyl acetal2회HCID 2531236-Chloro-2-methyl-3-nitropyridine

생성물 1

HCID 537327152-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A solution of 5 gm (29 mMol) 6-chloro-3-nitro-2-picoline in 40 mL dimethylformamide was treated with 5.83 mL (44 mMol) dimethylformamide dimethylacetal and the resulting mixture heated at 100° C. for 1.5 hours. At this point, 2 drops of triethylamine followed by 1.9 mL dimethylformamide dimethylacetal were added and heating continued for 2 more hours. The reaction mixture was concentrated under reduced pressure to provide the desired compound.

후처리

  1. additionwere added
  2. temperatureheating
  3. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1ebd330245274c77818e033abdec12bd
출처 데이터셋
uspto-grants-1999_05
특허 번호
US05905084

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