반응식
[I:1][C:2]1[C:3]([OH:16])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.Br[CH2:18][C:19]([C:21]1[S:25][CH:24]=[C:23]([C:26]([O:28][CH3:29])=[O:27])[CH:22]=1)=[O:20].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[I:1][C:2]1[C:3]([O:16][CH2:18][C:19]([C:21]2[S:25][CH:24]=[C:23]([C:26]([O:28][CH3:29])=[O:27])[CH:22]=2)=[O:20])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:12])([CH3:13])[C:10]=2[CH:11]=1참가 물질
5
반응물 3
생성물 1
시약·촉매·용매 1
실험 절차
A solution of 3-iodo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol (4 g, 12.1 mmol), methyl 5-bromoacetyl-3-thiophenecarboxylate (3.18 g, 12.1 mmol) and potassium carbonate (1.84 g, 13.3 mmol) in methyl ethyl ketone (100 ml), was heated under reflux for 4 h. The reaction medium was filtered and then concentrated in a rotary evaporator. The mixture was extracted with ethyl ether. The organic phase was washed with water, dried over magnesium sulfate and concentrated in a rotary evaporator under vacuum at 40° C.
후처리
- temperatureunder reflux for 4 h
- filtrationThe reaction medium was filtered
- concentrationconcentrated in a rotary evaporator
- extractionThe mixture was extracted with ethyl ether
- washThe organic phase was washed with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in a rotary evaporator under vacuum at 40° C.
출처 및 근거
- ORD 기록
- ord-f15a7a82bcb745ee9e03b7f2f77866b9
- 출처 데이터셋
- uspto-grants-1999_05
- 특허 번호
- US05905088
연결된 노트
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