Pyrrolidine → 2-Aminopyrazine-3-carboxylic acid pyrrolidide

HRID 1075767노트

반응식

HRID 1075767 반응식
[NH2:1][C:2]1[C:7]([C:8]([O:10]C)=O)=[N:6][CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>CO>[NH2:1][C:2]1[C:7]([C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:10])=[N:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 72669Methyl 3-aminopyrazinecarboxylate

생성물 1

HCID 539368772-Aminopyrazine-3-carboxylic acid pyrrolidide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 10 g. (0.065 mol) of methyl 2-aminopyrazine-3-carboxylate in 100 ml. of methanol and 25 ml. of pyrrolidine was refluxed for 18 hours. The residue obtained after evaporation under reduced pressure was triturated with ether to yield 8.8 g. (70%) of the above-named product as yellow crystals, with m.p. 100°-105°. A second crop of 2.3 g. (18%) with m.p. 95°-105° was obtained from the mother liquors. The analytical sample was recrystallized from 2-propanol. The pale yellow prisms had a melting point of 104°-106°.

후처리

  1. customThe residue obtained
  2. customafter evaporation under reduced pressure
  3. customwas triturated with ether
  4. customto yield 8.8 g
  5. custom(18%) with m.p. 95°-105° was obtained from the mother liquors
  6. customThe analytical sample was recrystallized from 2-propanol

출처 및 근거

ORD 기록
ord-67a7a9ff92cf4ffa887a17b8c8ce24d9
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954753

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