Ethanol → 10,11-Dihydro-3-methoxy-8-(methylthio)-dibenzo thiepin-10-ol

HRID 1075873노트

반응식

HRID 1075873 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11](=O)[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1.C([OH:23])C.[BH4-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12]3[CH2:11][CH:10]([OH:23])[CH:14]=[C:15]([S:18][CH3:19])[C:16]=3[CH:17]=[CH:9][S:8][C:7]=2[CH:20]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 128221953-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one

생성물 1

HCID 2154119710,11-Dihydro-3-methoxy-8-(methylthio)-dibenzo thiepin-10-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

17.8 G. of 3-methoxy-8-(methylthio)-dibenzo[b,f]thiepin-10(11H)-one is suspended in 150 ml. of ethanol and reacted with 38 g. of sodium borohydride. The reaction mixture is stirred for 90 minutes, and subsequently treated with water and extracted with ether. The organic phase is washed with water, dried over magnesium sulfate and evaporated, whereby there is obtained 10,11-dihydro-3-methoxy-8-(methylthio)-dibenzo[d,f]thiepin-10-ol having a melting point of 122°-124°.

후처리

  1. extractionextracted with ether
  2. washThe organic phase is washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-bee840270add48898f1237dbb4de0ce9
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954764

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