Hydrochloric Acid → HCID 21541490, 화합물

HRID 1076013노트

반응식

HRID 1076013 반응식
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12](=[O:19])[CH2:13][CH:14]([OH:18])[C:15]=1[C:16]#[N:17])([O:3][CH3:4])=[O:2].Cl>[Zn].C(O)(=O)C>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[CH:15]([C:16]#[N:17])[CH:14]([OH:18])[CH2:13][C:12]1=[O:19])([O:3][CH3:4])=[O:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 21541510HCID 21541510, 화합물

생성물 1

HCID 21541490HCID 21541490, 화합물수율 63.8%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

Into a mixture of 7 g of 2-(6'-carbomethoxyhexyl)-3-cyano-4-hydroxy-2-cyclopenten-1-one, 52.5 ml of acetic acid and 55 ml of 0.5 N hydrochloric acid was added 15 g of zinc powder. After the addition the reaction mixture was stirred for 3 hours under cooling. Thereafter, the zinc powder was removed by filtration, and the filtrate was diluted with water and extracted with ether. The ether extract was washed with a diluted aqueous sodium bicarbonate solution and with water and then dried. The solvent was distilled off to afford 4.5 g of 2-(6'-carbomethoxyhexyl)-3-cyano-4-hydroxy-cyclopentanone.

후처리

  1. additionAfter the addition the reaction mixture
  2. temperatureunder cooling
  3. customThereafter, the zinc powder was removed by filtration
  4. additionthe filtrate was diluted with water
  5. extractionextracted with ether
  6. extractionThe ether extract
  7. washwas washed with a diluted aqueous sodium bicarbonate solution and with water
  8. customdried
  9. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-a4da38e28eef44e5b7f9a511cb9e1918
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03954811

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